# SDHA

Source: https://onco.cc/targets/sdha/  
OnCo record `sdha` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SDHA (Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Renal cell carcinoma, Hepatocellular carcinoma and 5 more.

## Summary

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.81, somatic mutation 0.86, genetic literature 0.81). IntOGen calls it a driver in 3 cohorts (2 activating, 0 loss-of-function), covering Chromophobe Renal Cell Carcinoma, Hepatocellular Carcinoma, Low-Grade Glioma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: succinate dehydrogenase complex flavoprotein subunit A; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; SDH2
- Tags: cancer-genes-wave
- Symbol: SDHA
- Class: oncogene
- Biology: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Can act as a tumour suppressor. Location: Mitochondrion inner membrane (UniProt). Locus 5p15.33 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.84 with neuroendocrine neoplasm (MONDO_0019496); Renal cell carcinoma: IntOGen driver in 1 cohort (CHRCC); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903); Sarcomas: Open Targets association 0.52 with sarcoma (MONDO_0005089); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Adrenal Gland Pheochromocytoma; Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:10680: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10680
- UniProt P31040: https://www.uniprot.org/uniprotkb/P31040/entry
- NCBI Gene 6389: https://www.ncbi.nlm.nih.gov/gene/6389
- Ensembl ENSG00000073578: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073578

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastrointestinal stromal tumour (GIST)](https://onco.cc/cancers/gist/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/sdha.json