# SDHB

Source: https://onco.cc/targets/sdhb/  
OnCo record `sdhb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SDHB (Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Breast cancer and Gastrointestinal stromal tumour.

## Summary

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.

CIViC holds 3 clinical evidence items and 0 assertions across 4 variants, naming Vandetanib and Metformin. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.32, genetic association 0.61, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: succinate dehydrogenase complex iron sulfur subunit B; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; SDH1
- Tags: cancer-genes-wave
- Symbol: SDHB
- Class: enzyme
- Biology: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1p36.13 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.88 with neuroendocrine neoplasm (MONDO_0019496); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); Gastrointestinal stromal tumour: Open Targets association 0.75 with gastrointestinal stromal tumour (MONDO_0011719)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Paraganglioma; Hereditary Renal Cell Carcinoma.

## Sources

- HGNC HGNC:10681: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10681
- UniProt P21912: https://www.uniprot.org/uniprotkb/P21912/entry
- NCBI Gene 6390: https://www.ncbi.nlm.nih.gov/gene/6390
- Ensembl ENSG00000117118: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117118

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Gastrointestinal stromal tumour (GIST)](https://onco.cc/cancers/gist/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)

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JSON: https://onco.cc/api/v1/entities/sdhb.json