# SDHC

Source: https://onco.cc/targets/sdhc/  
OnCo record `sdhc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.

## Summary

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.

Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.91, genetic association 0.43, somatic mutation 0.97, animal model 0.38).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: succinate dehydrogenase complex subunit C; Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; CYB560; cybL; PGL3
- Tags: cancer-genes-wave
- Symbol: SDHC
- Class: other
- Biology: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1q23.3 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.83 with neuroendocrine neoplasm (MONDO_0019496); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575); Gastrointestinal stromal tumour: Open Targets association 0.72 with gastrointestinal stromal tumour (MONDO_0011719)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10682: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10682
- UniProt Q99643: https://www.uniprot.org/uniprotkb/Q99643/entry
- NCBI Gene 6391: https://www.ncbi.nlm.nih.gov/gene/6391
- Ensembl ENSG00000143252: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143252

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastrointestinal stromal tumour (GIST)](https://onco.cc/cancers/gist/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)

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JSON: https://onco.cc/api/v1/entities/sdhc.json