# SET

Source: https://onco.cc/targets/set/  
OnCo record `set` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SET (SET nuclear proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.

## Summary

Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.

Open Targets scores its association with cancer at 0.46 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.59).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SET nuclear proto-oncogene; PHAPII; 2PP2A; IPP2A2; TAF-IBETA; IGAAD; TAF-I
- Tags: cancer-genes-wave
- Symbol: SET
- Class: other
- Biology: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. Location: Cytoplasm, cytosol; Endoplasmic reticulum; Nucleus, nucleoplasm (UniProt). Locus 9q34.11 (HGNC).
- Where found: Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.52 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10760: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10760
- UniProt Q01105: https://www.uniprot.org/uniprotkb/Q01105/entry
- NCBI Gene 6418: https://www.ncbi.nlm.nih.gov/gene/6418
- Ensembl ENSG00000119335: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119335

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/set.json