# SFPQ

Source: https://onco.cc/targets/sfpq/  
OnCo record `sfpq` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SFPQ (Splicing factor, proline- and glutamine-rich) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner and a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, somatic mutation 0.89).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: splicing factor proline and glutamine rich; Splicing factor, proline- and glutamine-rich; PPP1R140
- Tags: cancer-genes-wave
- Symbol: SFPQ
- Class: transcription
- Biology: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Location: Nucleus speckle; Nucleus matrix; Cytoplasm (UniProt). Locus 1p34.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene; UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10774: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10774
- UniProt P23246: https://www.uniprot.org/uniprotkb/P23246/entry
- NCBI Gene 6421: https://www.ncbi.nlm.nih.gov/gene/6421
- Ensembl ENSG00000116560: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116560

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/sfpq.json