# SFRP4

Source: https://onco.cc/targets/sfrp4/  
OnCo record `sfrp4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.

## Summary

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, animal model 0.54, genetic association 0.14, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: secreted frizzled related protein 4; Secreted frizzled-related protein 4; frpHE; FRP-4; FRPHE; FRZB-2
- Tags: cancer-genes-wave
- Symbol: SFRP4
- Class: other
- Biology: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signalling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Location: Secreted (UniProt). Locus 7p14.1 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056); Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10778: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10778
- UniProt Q6FHJ7: https://www.uniprot.org/uniprotkb/Q6FHJ7/entry
- NCBI Gene 6424: https://www.ncbi.nlm.nih.gov/gene/6424
- Ensembl ENSG00000106483: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106483

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/sfrp4.json