# SH3GL1

Source: https://onco.cc/targets/sh3gl1/  
OnCo record `sh3gl1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.01, somatic mutation 0.95).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SH3 domain containing GRB2 like 1, endophilin A2; Endophilin-A2; SH3P8; SH3D2B; CNSA1; MGC111371
- Tags: cancer-genes-wave
- Symbol: SH3GL1
- Class: other
- Biology: Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Location: Cytoplasm; Early endosome membrane; Cell projection, podosome (UniProt). Locus 19p13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10830: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10830
- UniProt Q99961: https://www.uniprot.org/uniprotkb/Q99961/entry
- NCBI Gene 6455: https://www.ncbi.nlm.nih.gov/gene/6455
- Ensembl ENSG00000141985: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141985

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/sh3gl1.json