# SIDT1

Source: https://onco.cc/targets/sidt1/  
OnCo record `sidt1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.65).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SID1 transmembrane family member 1; FLJ20174; SID-1
- Tags: cancer-genes-wave
- Symbol: SIDT1
- Class: other
- Biology: In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Location: Membrane (UniProt). Locus 3q13.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25967: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25967
- UniProt Q9NXL6: https://www.uniprot.org/uniprotkb/Q9NXL6/entry
- NCBI Gene 54847: https://www.ncbi.nlm.nih.gov/gene/54847
- Ensembl ENSG00000072858: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072858

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/sidt1.json