# Siglec-10

Source: https://onco.cc/targets/siglec10/  
OnCo record `siglec10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.

## Summary

SIGLEC10 (chromosome 19q13.41) is a sialic-acid-binding immunoglobulin-like lectin that preferentially binds alpha-2,3- or alpha-2,6-linked sialic acid and seems to act as an inhibitory receptor in the immune response, recruiting cytoplasmic phosphatases through its ITIMs on ligand-induced phosphorylation; it is expressed by peripheral blood leukocytes (eosinophils, monocytes and an NK-cell subpopulation) and in lymph node, lung, ovary and appendix (UniProt Q96LC7). The CD24-Siglec-10 interaction inhibits macrophage phagocytosis and NK cytotoxicity (Panagiotou et al. 2022).

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: SIGLEC-10; sialic acid binding Ig like lectin 10; SLG2
- Tags: checkpoint-map
- Symbol: SIGLEC10
- Class: checkpoint
- Biology: An ITIM-bearing Siglec; the receptor half of the CD24 pair.
- Where found: Eosinophils, monocytes, an NK subpopulation (UniProt Q96LC7)

## Notes

- Prevalence not recorded: HGNC and UniProt carry no positivity rates.

## Sources

- HGNC HGNC:15620: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15620
- UniProt Q96LC7: https://www.uniprot.org/uniprotkb/Q96LC7/entry
- NCBI Gene 89790: https://www.ncbi.nlm.nih.gov/gene/89790

## Connected records

- targets: [CD24](https://onco.cc/targets/cd24/), [SIRPA](https://onco.cc/targets/sirpa/)
- terms: [Checkpoint (two meanings)](https://onco.cc/terms/checkpoint/), [Macrophage](https://onco.cc/terms/macrophage/)
- pathways: [The cancer-immunity cycle](https://onco.cc/pathways/cancer-immunity-cycle/)

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JSON: https://onco.cc/api/v1/entities/siglec10.json