# SIM2

Source: https://onco.cc/targets/sim2/  
OnCo record `sim2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.40, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SIM bHLH transcription factor 2; Single-minded homolog 2; MGC119447; bHLHe15
- Tags: cancer-genes-wave
- Symbol: SIM2
- Class: transcription
- Biology: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Location: Nucleus (UniProt). Locus 21q22.13 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10883: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10883
- UniProt Q14190: https://www.uniprot.org/uniprotkb/Q14190/entry
- NCBI Gene 6493: https://www.ncbi.nlm.nih.gov/gene/6493
- Ensembl ENSG00000159263: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000159263

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/sim2.json