# A Study of SIM0270 Combined With Everolimus vs. Treatment of Physician's Choice in Patients With ER+/HER2- Advanced Breast Cancer (SIMRISE)

Source: https://onco.cc/trials/simrise/  
OnCo record `simrise` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing SIM0270 in HR-positive / HER2-negative breast cancer, active and no longer recruiting.

## Summary

A Study of SIM0270 Combined With Everolimus vs. Treatment of Physician's Choice in Patients With ER+/HER2- Advanced Breast Cancer (SIMRISE) is a phase 3 interventional study registered as NCT06680921, led by Jiangsu Simcere Pharmaceutical with Nanjing Zaiming Pharmaceutical, and active but no longer recruiting on the registry. Official title: A Randomised, Open-label, Phase III Study of SIM0270 Combined With Everolimus Versus Treatment of Physician's Choice in Patients With CDK4/6 Inhibitors Previously Treated, ER+/HER2- Locally Advanced or Metastatic Breast Cancer. Planned enrolment is 482 participants (actual). The study started in 2024-11-14 and primary completion is expected in 2028-08-31. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-11
- Also known as: SIMRISE
- Tags: ctgov-ingest
- Registry id: NCT06680921
- Phase: 3
- Setting: A Randomized, Open-label, Phase III Study of SIM0270 Combined With Everolimus Versus Treatment of Physician's Choice in Patients With CDK4/6 Inhibitors Previously Treated, ER+/HER2- Locally Advanced or Metastatic Breast Cancer
- Sponsor: Jiangsu Simcere Pharmaceutical
- Enrolled: 482

## Sources

- ClinicalTrials.gov NCT06680921: https://clinicaltrials.gov/study/NCT06680921

## Connected records

- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/), [HR-positive metastatic breast cancer after CDK4/6 inhibitors](https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/)
- drugs: [SIM0270](https://onco.cc/drugs/sim0270/)
- companies: [Simcere Pharmaceutical](https://onco.cc/companies/simcere/)

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JSON: https://onco.cc/api/v1/entities/simrise.json