# SKIL

Source: https://onco.cc/targets/skil/  
OnCo record `skil` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SKIL (Ski-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

May have regulatory role in cell division or differentiation in response to extracellular signals.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.95, animal model 0.37, genetic association 0.62, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SKI like proto-oncogene; Ski-like protein; SnoN; SnoA
- Tags: cancer-genes-wave
- Symbol: SKIL
- Class: other
- Biology: May have regulatory role in cell division or differentiation in response to extracellular signals. Locus 3q26.2 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10897: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10897
- UniProt P12757: https://www.uniprot.org/uniprotkb/P12757/entry
- NCBI Gene 6498: https://www.ncbi.nlm.nih.gov/gene/6498
- Ensembl ENSG00000136603: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136603

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/skil.json