# SLC12A2

Source: https://onco.cc/targets/slc12a2/  
OnCo record `slc12a2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.

## Summary

Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Temozolomide and Antisecretory Factor-enriched Egg Yolk Powder Supplement.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 12 member 2; Solute carrier family 12 member 2; NKCC1; BSC2; BSC-2; PPP1R141; CCC1
- Tags: cancer-genes-wave
- Symbol: SLC12A2
- Class: other
- Biology: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. Location: Basolateral cell membrane (UniProt). Locus 5q23.3 (HGNC).
- Where found: Glioma & glioblastoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10911: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10911
- UniProt P55011: https://www.uniprot.org/uniprotkb/P55011/entry
- NCBI Gene 6558: https://www.ncbi.nlm.nih.gov/gene/6558
- Ensembl ENSG00000064651: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000064651

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)

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JSON: https://onco.cc/api/v1/entities/slc12a2.json