# SLC22A3

Source: https://onco.cc/targets/slc22a3/  
OnCo record `slc22a3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC22A3 (Solute carrier family 22 member 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.68).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 22 member 3; Solute carrier family 22 member 3; OCT3
- Tags: cancer-genes-wave
- Symbol: SLC22A3
- Class: other
- Biology: Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow. Location: Cell membrane; Apical cell membrane; Basolateral cell membrane; Mitochondrion membrane (UniProt). Locus 6q25.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10967: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10967
- UniProt O75751: https://www.uniprot.org/uniprotkb/O75751/entry
- NCBI Gene 6581: https://www.ncbi.nlm.nih.gov/gene/6581
- Ensembl ENSG00000146477: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146477

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/slc22a3.json