# SLC24A5

Source: https://onco.cc/targets/slc24a5/  
OnCo record `slc24a5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.

## Summary

Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.08, animal model 0.56, genetic association 0.70).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 24 member 5; Sodium/potassium/calcium exchanger 5; OCA6; NCKX5
- Tags: cancer-genes-wave
- Symbol: SLC24A5
- Class: other
- Biology: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes. Location: Golgi apparatus, trans-Golgi network membrane; Melanosome (UniProt). Locus 15q21.1 (HGNC).
- Where found: Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20611: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20611
- UniProt Q71RS6: https://www.uniprot.org/uniprotkb/Q71RS6/entry
- NCBI Gene 283652: https://www.ncbi.nlm.nih.gov/gene/283652
- Ensembl ENSG00000188467: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188467

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/slc24a5.json