# SLC25A11

Source: https://onco.cc/targets/slc25a11/  
OnCo record `slc25a11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC25A11 (Mitochondrial 2-oxoglutarate/malate carrier protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.

## Summary

Catalyses the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 25 member 11; Mitochondrial 2-oxoglutarate/malate carrier protein; SLC20A4
- Tags: cancer-genes-wave
- Symbol: SLC25A11
- Class: other
- Biology: Catalyses the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Does not transport glutathione. In addition can facilitate proton transport in the presence of protonophores such as long-chain fatty acids, contributing to mitochondrial uncoupling and regulation of mitochondrial energetic efficiency. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism. Location: Mitochondrion inner membrane (UniProt). Locus 17p13.2 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.69 with neuroendocrine neoplasm (MONDO_0019496)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10981: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10981
- UniProt Q02978: https://www.uniprot.org/uniprotkb/Q02978/entry
- NCBI Gene 8402: https://www.ncbi.nlm.nih.gov/gene/8402
- Ensembl ENSG00000108528: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108528

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)

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JSON: https://onco.cc/api/v1/entities/slc25a11.json