# SLC29A1

Source: https://onco.cc/targets/slc29a1/  
OnCo record `slc29a1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC29A1 (Equilibrative nucleoside transporter 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 29 member 1 (Augustine blood group); Equilibrative nucleoside transporter 1; ENT1
- Tags: cancer-genes-wave
- Symbol: SLC29A1
- Class: other
- Biology: Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles. Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier. Location: Basolateral cell membrane; Apical cell membrane; Cell membrane (UniProt). Locus 6p21.1 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11003: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11003
- UniProt Q99808: https://www.uniprot.org/uniprotkb/Q99808/entry
- NCBI Gene 2030: https://www.ncbi.nlm.nih.gov/gene/2030
- Ensembl ENSG00000112759: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112759

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/slc29a1.json