# SLC45A2

Source: https://onco.cc/targets/slc45a2/  
OnCo record `slc45a2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.

## Summary

Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.90, animal model 0.47, genetic association 0.71).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 45 member 2; Membrane-associated transporter protein; AIM-1; OCA4
- Tags: cancer-genes-wave
- Symbol: SLC45A2
- Class: other
- Biology: Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralisation that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR. Location: Melanosome membrane (UniProt). Locus 5p13.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105); Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16472: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16472
- UniProt Q9UMX9: https://www.uniprot.org/uniprotkb/Q9UMX9/entry
- NCBI Gene 51151: https://www.ncbi.nlm.nih.gov/gene/51151
- Ensembl ENSG00000164175: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164175

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/slc45a2.json