# SLC67A1

Source: https://onco.cc/targets/slc67a1/  
OnCo record `slc67a1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes genetic literature 0.38, affected pathway 0.76, literature 0.89, genetic association 0.09, somatic mutation 0.71, animal model 0.35).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 67 member 1; Solute carrier family 67 member A1; BWR1A; TSSC5; IMPT1; ORCTL2; BWSCR1A; SLC22A18; SLC22A1L
- Tags: cancer-genes-wave
- Symbol: SLC67A1
- Class: other
- Biology: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism. Location: Apical cell membrane (UniProt). Locus 11p15.4 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10964: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10964
- UniProt Q96BI1: https://www.uniprot.org/uniprotkb/Q96BI1/entry
- NCBI Gene 5002: https://www.ncbi.nlm.nih.gov/gene/5002
- Ensembl ENSG00000110628: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110628

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/slc67a1.json