# SLC6A3

Source: https://onco.cc/targets/slc6a3/  
OnCo record `slc6a3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLC6A3 (Sodium-dependent dopamine transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signalling.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.83, animal model 0.53, genetic association 0.00, clinical 0.88).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier family 6 member 3; Sodium-dependent dopamine transporter; DAT1
- Tags: cancer-genes-wave
- Symbol: SLC6A3
- Class: other
- Biology: Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signalling. Location: Cell membrane; Cell projection, neuron projection; Cell projection, axon (UniProt). Locus 5p15.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.88. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11049: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11049
- UniProt Q01959: https://www.uniprot.org/uniprotkb/Q01959/entry
- NCBI Gene 6531: https://www.ncbi.nlm.nih.gov/gene/6531
- Ensembl ENSG00000142319: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142319

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/slc6a3.json