# SLCO1B1

Source: https://onco.cc/targets/slco1b1/  
OnCo record `slco1b1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLCO1B1 (Solute carrier organic anion transporter family member 1B1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Methotrexate.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: solute carrier organic anion transporter family member 1B1; Solute carrier organic anion transporter family member 1B1; OATP-C; LST-1; OATP1B1; SLC21A6
- Tags: cancer-genes-wave
- Symbol: SLCO1B1
- Class: other
- Biology: Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier. Location: Basolateral cell membrane; Basal cell membrane (UniProt). Locus 12p12.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10959: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10959
- UniProt Q9Y6L6: https://www.uniprot.org/uniprotkb/Q9Y6L6/entry
- NCBI Gene 10599: https://www.ncbi.nlm.nih.gov/gene/10599
- Ensembl ENSG00000134538: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134538

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/slco1b1.json