# SLX4

Source: https://onco.cc/targets/slx4/  
OnCo record `slx4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SLX4 (Structure-specific endonuclease subunit SLX4) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms, Leukaemia, Myeloproliferative neoplasms and 1 more.

## Summary

Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.58, animal model 0.26, genetic association 0.53, genetic literature 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SLX4 structure-specific endonuclease subunit; Structure-specific endonuclease subunit SLX4; KIAA1784; KIAA1987; FANCP; BTBD12
- Tags: cancer-genes-wave
- Symbol: SLX4
- Class: other
- Biology: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Location: Nucleus (UniProt). Locus 16p13.3 (HGNC).
- Where found: Myelodysplastic syndromes / neoplasms: Open Targets association 0.51 with myelodysplastic syndrome (MONDO_0018881); Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.51 with myeloproliferative neoplasm (MONDO_0020076); Acute myeloid leukaemia: Open Targets association 0.51 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23845: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23845
- UniProt Q8IY92: https://www.uniprot.org/uniprotkb/Q8IY92/entry
- NCBI Gene 84464: https://www.ncbi.nlm.nih.gov/gene/84464
- Ensembl ENSG00000188827: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188827

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/slx4.json