# SMAD7

Source: https://onco.cc/targets/smad7/  
OnCo record `smad7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SMAD7 (SMAD family member 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.99, animal model 0.41, genetic association 0.77).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SMAD family member 7; MADH8; MADH7
- Tags: cancer-genes-wave
- Symbol: SMAD7
- Class: transcription
- Biology: Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Location: Nucleus; Cytoplasm (UniProt). Locus 18q21.1 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6773: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6773
- UniProt O15105: https://www.uniprot.org/uniprotkb/O15105/entry
- NCBI Gene 4092: https://www.ncbi.nlm.nih.gov/gene/4092
- Ensembl ENSG00000101665: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101665

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/smad7.json