# SMARCD1

Source: https://onco.cc/targets/smarcd1/  
OnCo record `smarcd1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SMARCD1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.

## Summary

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Malignant Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SWI/SNF related BAF chromatin remodeling complex subunit D1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; BAF60A; Rsc6p; CRACD1
- Tags: cancer-genes-wave
- Symbol: SMARCD1
- Class: tumor-suppressor
- Biology: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). Location: Nucleus (UniProt). Locus 12q13.12 (HGNC).
- Where found: Breast cancer: IntOGen driver in 1 cohort (BRCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11106: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11106
- UniProt Q96GM5: https://www.uniprot.org/uniprotkb/Q96GM5/entry
- NCBI Gene 6602: https://www.ncbi.nlm.nih.gov/gene/6602
- Ensembl ENSG00000066117: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000066117

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/smarcd1.json