# SMARCE1

Source: https://onco.cc/targets/smarce1/  
OnCo record `smarce1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SMARCE1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Meningioma.

## Summary

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.02, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SWI/SNF related BAF chromatin remodeling complex subunit E1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BAF57
- Tags: cancer-genes-wave
- Symbol: SMARCE1
- Class: other
- Biology: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). Location: Nucleus (UniProt). Locus 17q21.2 (HGNC).
- Where found: Meningioma: Open Targets association 0.79 with meningioma (MONDO_0016642)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11109: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11109
- UniProt Q969G3: https://www.uniprot.org/uniprotkb/Q969G3/entry
- NCBI Gene 6605: https://www.ncbi.nlm.nih.gov/gene/6605
- Ensembl ENSG00000073584: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073584

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Meningioma](https://onco.cc/cancers/meningioma/)

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JSON: https://onco.cc/api/v1/entities/smarce1.json