# SNCAIP

Source: https://onco.cc/targets/sncaip/  
OnCo record `sncaip` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SNCAIP (Synphilin-1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: synuclein alpha interacting protein; Synphilin-1; SYPH1
- Tags: cancer-genes-wave
- Symbol: SNCAIP
- Class: other
- Biology: Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Location: Cytoplasm (UniProt). Locus 5q23.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Medulloblastoma Non-WNT/non-SHH Group 4.

## Sources

- HGNC HGNC:11139: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11139
- UniProt Q9Y6H5: https://www.uniprot.org/uniprotkb/Q9Y6H5/entry
- NCBI Gene 9627: https://www.ncbi.nlm.nih.gov/gene/9627
- Ensembl ENSG00000064692: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000064692

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/sncaip.json