# SND1

Source: https://onco.cc/targets/snd1/  
OnCo record `snd1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.

## Summary

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor.

Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.98, genetic association 0.03, somatic mutation 0.83, animal model 0.38). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cervical Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: staphylococcal nuclease and tudor domain containing 1; Staphylococcal nuclease domain-containing protein 1; TDRD11; p100
- Tags: cancer-genes-wave
- Symbol: SND1
- Class: oncogene
- Biology: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. Location: Cytoplasm; Nucleus; Melanosome (UniProt). Locus 7q32.1 (HGNC).
- Where found: Cervical cancer: IntOGen driver in 1 cohort (CESC); Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903); Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575); Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908); Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30646: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30646
- UniProt Q7KZF4: https://www.uniprot.org/uniprotkb/Q7KZF4/entry
- NCBI Gene 27044: https://www.ncbi.nlm.nih.gov/gene/27044
- Ensembl ENSG00000197157: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197157

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Cervical cancer](https://onco.cc/cancers/cervical/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/snd1.json