# SNTB1

Source: https://onco.cc/targets/sntb1/  
OnCo record `sntb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.71).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: syntrophin beta 1; Beta-1-syntrophin; 59-DAP; A1B; BSYN2; TIP-43; SNT2; SNT2B1
- Tags: cancer-genes-wave
- Symbol: SNTB1
- Class: other
- Biology: Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Location: Cell membrane, sarcolemma; Cell junction; Cytoplasm, cytoskeleton (UniProt). Locus 8q24.12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11168: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11168
- UniProt Q13884: https://www.uniprot.org/uniprotkb/Q13884/entry
- NCBI Gene 6641: https://www.ncbi.nlm.nih.gov/gene/6641
- Ensembl ENSG00000172164: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172164

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/sntb1.json