# SNW1

Source: https://onco.cc/targets/snw1/  
OnCo record `snw1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SNW1 (SNW domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.95, genetic association 0.03).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SNW domain containing 1; SNW domain-containing protein 1; NCoA-62; Prp45; PRPF45; Bx42; SKIP1; FUN20; SKIIP
- Tags: cancer-genes-wave
- Symbol: SNW1
- Class: transcription
- Biology: Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 14q24.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16696: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16696
- UniProt Q13573: https://www.uniprot.org/uniprotkb/Q13573/entry
- NCBI Gene 22938: https://www.ncbi.nlm.nih.gov/gene/22938
- Ensembl ENSG00000100603: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100603

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/snw1.json