# SNX29

Source: https://onco.cc/targets/snx29/  
OnCo record `snx29` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.

## Summary

UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29".

IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Small Intestinal Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sorting nexin 29; Sorting nexin-29; FLJ12363; RUNDC2A
- Tags: cancer-genes-wave
- Symbol: SNX29
- Class: tumor-suppressor
- Biology: UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29". Locus 16p13.13-p13.12 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA); Small intestine cancer: IntOGen driver in 1 cohort (SIC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30542: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30542
- UniProt Q8TEQ0: https://www.uniprot.org/uniprotkb/Q8TEQ0/entry
- NCBI Gene 92017: https://www.ncbi.nlm.nih.gov/gene/92017
- Ensembl ENSG00000048471: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000048471

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Small intestine cancer (small bowel adenocarcinoma)](https://onco.cc/cancers/small-bowel/)

---
JSON: https://onco.cc/api/v1/entities/snx29.json