# SORCS3

Source: https://onco.cc/targets/sorcs3/  
OnCo record `sorcs3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.63).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sortilin related VPS10 domain containing receptor 3; VPS10 domain-containing receptor SorCS3; KIAA1059; SORCS
- Tags: cancer-genes-wave
- Symbol: SORCS3
- Class: other
- Biology: Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density. Location: Cell membrane; Synaptic cell membrane; Postsynaptic density (UniProt). Locus 10q25.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16699: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16699
- UniProt Q9UPU3: https://www.uniprot.org/uniprotkb/Q9UPU3/entry
- NCBI Gene 22986: https://www.ncbi.nlm.nih.gov/gene/22986
- Ensembl ENSG00000156395: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156395

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/sorcs3.json