# Sovilnesib

Source: https://onco.cc/drugs/sovilnesib/  
OnCo record `sovilnesib` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Sovilnesib is an experimental pill from Volastra Therapeutics, in phase 1 trials for high-grade serous ovarian cancer.

## Summary

Sovilnesib (AMG 650) is a small molecule, oral from Volastra Therapeutics. Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Volastra in-licensed it from Amgen in February 2023. NCT04293094 began in 2020 as Amgen's first study of AMG 650 in advanced solid tumours and is completed; NCT06084416 is recruiting people with high-grade serous ovarian, fallopian tube or primary peritoneal cancer. The company reports an FDA Fast Track designation in platinum-resistant high-grade serous ovarian cancer. Whether it works in people has not been established.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-04
- Also known as: AMG650; AMG-650
- Tags: pipeline; ctgov-ingest
- Code: AMG 650
- Modality: Small molecule, oral
- Mechanism: Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide.

## Sources

- Volastra Therapeutics pipeline: https://www.volastratx.com/pipeline/
- Volastra partnerships and deals: https://www.volastratx.com/partnerships-and-deals/
- ClinicalTrials.gov NCT06084416: https://clinicaltrials.gov/study/NCT06084416
- ClinicalTrials.gov NCT04293094: https://clinicaltrials.gov/study/NCT04293094

## Connected records

- cancers: [High-grade serous ovarian cancer](https://onco.cc/cancers/high-grade-serous-ovarian-cancer/)
- targets: [KIF18A](https://onco.cc/targets/kif18a/)
- companies: [Volastra Therapeutics](https://onco.cc/companies/volastra-therapeutics/)
- trials: [A Study of Sovilnesib in Subjects With Ovarian Cancer](https://onco.cc/trials/nct06084416/), [Study of AMG 650 in Adult Participants With Advanced Solid Tumors](https://onco.cc/trials/nct04293094/)

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JSON: https://onco.cc/api/v1/entities/sovilnesib.json