# SOX10

Source: https://onco.cc/targets/sox10/  
OnCo record `sox10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SOX10 (Transcription factor SOX-10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.

## Summary

Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SRY-box transcription factor 10; Transcription factor SOX-10; WS4; WS2E; SOX-10
- Tags: cancer-genes-wave
- Symbol: SOX10
- Class: transcription
- Biology: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. Location: Cytoplasm; Nucleus; Mitochondrion outer membrane (UniProt). Locus 22q13.1 (HGNC).
- Where found: Melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11190: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11190
- UniProt P56693: https://www.uniprot.org/uniprotkb/P56693/entry
- NCBI Gene 6663: https://www.ncbi.nlm.nih.gov/gene/6663
- Ensembl ENSG00000100146: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100146

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

---
JSON: https://onco.cc/api/v1/entities/sox10.json