# SOX17

Source: https://onco.cc/targets/sox17/  
OnCo record `sox17` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SOX17 (Transcription factor SOX-17) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.

## Summary

Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SRY-box transcription factor 17; Transcription factor SOX-17
- Tags: cancer-genes-wave
- Symbol: SOX17
- Class: oncogene
- Biology: Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signalling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Location: Nucleus (UniProt). Locus 8q11.23 (HGNC).
- Where found: Endometrial cancer: IntOGen driver in 1 cohort (UCEC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18122: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18122
- UniProt Q9H6I2: https://www.uniprot.org/uniprotkb/Q9H6I2/entry
- NCBI Gene 64321: https://www.ncbi.nlm.nih.gov/gene/64321
- Ensembl ENSG00000164736: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164736

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/)

---
JSON: https://onco.cc/api/v1/entities/sox17.json