# SP140

Source: https://onco.cc/targets/sp140/  
OnCo record `sp140` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SP140 (Nuclear body protein SP140) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma and Mantle cell lymphoma.

## Summary

Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukaemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SP140 nuclear body protein; Nuclear body protein SP140; LYSP100-B; LYSP100-A
- Tags: cancer-genes-wave
- Symbol: SP140
- Class: tumor-suppressor
- Biology: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukaemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. Location: Nucleus; Nucleus, PML body; Cytoplasm (UniProt). Locus 2q37.1 (HGNC).
- Where found: Multiple myeloma: IntOGen driver in 1 cohort (PCM); Mantle cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17133: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17133
- UniProt Q13342: https://www.uniprot.org/uniprotkb/Q13342/entry
- NCBI Gene 11262: https://www.ncbi.nlm.nih.gov/gene/11262
- Ensembl ENSG00000079263: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079263

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Mantle cell lymphoma](https://onco.cc/cancers/mantle-cell-lymphoma/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/)

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JSON: https://onco.cc/api/v1/entities/sp140.json