# SPDL1

Source: https://onco.cc/targets/spdl1/  
OnCo record `spdl1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.73).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: spindle apparatus coiled-coil protein 1; FLJ20364; hSpindly; CCDC99
- Tags: cancer-genes-wave
- Symbol: SPDL1
- Class: other
- Biology: Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 5q35.1 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:26010: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26010
- UniProt Q96EA4: https://www.uniprot.org/uniprotkb/Q96EA4/entry
- NCBI Gene 54908: https://www.ncbi.nlm.nih.gov/gene/54908
- Ensembl ENSG00000040275: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000040275

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/spdl1.json