# SPRY2

Source: https://onco.cc/targets/spry2/  
OnCo record `spry2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SPRY2 (Protein sprouty homolog 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.

## Summary

Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fibre differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sprouty RTK signaling antagonist 2; Protein sprouty homolog 2; hSPRY2
- Tags: cancer-genes-wave
- Symbol: SPRY2
- Class: other
- Biology: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fibre differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination. Location: Cytoplasm, cytoskeleton; Cell projection, ruffle membrane (UniProt). Locus 13q31.1 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11270: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11270
- UniProt O43597: https://www.uniprot.org/uniprotkb/O43597/entry
- NCBI Gene 10253: https://www.ncbi.nlm.nih.gov/gene/10253
- Ensembl ENSG00000136158: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136158

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/spry2.json