# SPTBN1

Source: https://onco.cc/targets/sptbn1/  
OnCo record `sptbn1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.95, animal model 0.51, genetic association 0.28).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: spectrin beta, non-erythrocytic 1; Spectrin beta chain, non-erythrocytic 1
- Tags: cancer-genes-wave
- Symbol: SPTBN1
- Class: other
- Biology: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. Location: Cytoplasm, cytoskeleton; Cytoplasm, myofibril, sarcomere, M line; Cytoplasm, cytosol; Cell membrane (UniProt). Locus 2p16.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11275: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11275
- UniProt Q01082: https://www.uniprot.org/uniprotkb/Q01082/entry
- NCBI Gene 6711: https://www.ncbi.nlm.nih.gov/gene/6711
- Ensembl ENSG00000115306: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115306

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/sptbn1.json