# SRC family kinases

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## TL;DR

The first cancer gene ever identified, a kinase that relays growth, adhesion and movement signals. Dasatinib and bosutinib were designed as BCR::ABL1 drugs but also hit SRC-family kinases, part of the reason they work when imatinib has failed.

## Summary

SRC, discovered through the Rous sarcoma virus, heads a family of non-receptor tyrosine kinases (SRC, LYN, LCK, HCK, FYN, YES1) that sit downstream of growth-factor receptors and integrins. Dasatinib and bosutinib inhibit both BCR::ABL1 and SRC-family kinases and are approved for chronic myeloid leukaemia and, for dasatinib, Philadelphia chromosome-positive acute lymphoblastic leukaemia; LYN signalling contributes to imatinib resistance, so the dual activity matters. Selective SRC inhibitors have not succeeded in solid tumours despite frequent SRC activation, a reminder that activation and dependency are not the same thing.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Symbol: SRC
- Class: kinase
- Biology: Non-receptor tyrosine kinase family downstream of receptor tyrosine kinases and integrins; dual BCR::ABL1 and SRC-family inhibition by dasatinib and bosutinib.
- Where found: Chronic myeloid leukaemia and Ph-positive ALL (as a secondary target); Activated in many solid tumours without proven dependency

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Proto-oncogene_tyrosine-protein_kinase_Src
- UniProt P12931: SRC: https://www.uniprot.org/uniprotkb/P12931/entry

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Chronic myeloid leukaemia (CML)](https://onco.cc/cancers/cml/)
- drugs: [Bosutinib](https://onco.cc/drugs/bosutinib/), [Dasatinib](https://onco.cc/drugs/dasatinib/)
- trials: [READY](https://onco.cc/trials/ready-dasatinib/)
- targets: [FRK kinase](https://onco.cc/targets/frk/), [HCK kinase](https://onco.cc/targets/hck/), [LYN kinase](https://onco.cc/targets/lyn/), [PTK6 (BRK)](https://onco.cc/targets/ptk6/)

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