# SRGAP1

Source: https://onco.cc/targets/srgap1/  
OnCo record `srgap1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SRGAP1 (SLIT-ROBO Rho GTPase-activating protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.

## Summary

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signalling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.82, genetic literature 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SLIT-ROBO Rho GTPase activating protein 1; SLIT-ROBO Rho GTPase-activating protein 1; KIAA1304; ARHGAP13
- Tags: cancer-genes-wave
- Symbol: SRGAP1
- Class: other
- Biology: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signalling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. Locus 12q14.2 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.69 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17382: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17382
- UniProt Q7Z6B7: https://www.uniprot.org/uniprotkb/Q7Z6B7/entry
- NCBI Gene 57522: https://www.ncbi.nlm.nih.gov/gene/57522
- Ensembl ENSG00000196935: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196935

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/srgap1.json