# SRGAP3

Source: https://onco.cc/targets/srgap3/  
OnCo record `srgap3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.

## Summary

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SLIT-ROBO Rho GTPase activating protein 3; SLIT-ROBO Rho GTPase-activating protein 3; KIAA0411; MEGAP; ARHGAP14; SRGAP2
- Tags: cancer-genes-wave
- Symbol: SRGAP3
- Class: oncogene
- Biology: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons. Locus 3p25.3 (HGNC).
- Where found: Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19744: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19744
- UniProt O43295: https://www.uniprot.org/uniprotkb/O43295/entry
- NCBI Gene 9901: https://www.ncbi.nlm.nih.gov/gene/9901
- Ensembl ENSG00000196220: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196220

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Pleural mesothelioma](https://onco.cc/cancers/pleural-mesothelioma/)

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JSON: https://onco.cc/api/v1/entities/srgap3.json