# SRMS

Source: https://onco.cc/targets/srms/  
OnCo record `srms` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SRMS (Tyrosine-protein kinase Srms) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Non-Hodgkin lymphoma and 2 more.

## Summary

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.40, genetic association 0.00, clinical 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; Tyrosine-protein kinase Srms; dJ697K14.1; PTK70; C20orf148
- Tags: cancer-genes-wave
- Symbol: SRMS
- Class: kinase
- Biology: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR. Location: Cytoplasm (UniProt). Locus 20q13.33 (HGNC).
- Where found: Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.58 with myeloproliferative neoplasm (MONDO_0020076); Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908); Chronic myeloid leukaemia: Open Targets association 0.58 with chronic myelogenous leukaemia, BCR-ABL1 positive (MONDO_0011996); Acute lymphoblastic leukaemia: Open Targets association 0.54 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.97. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11298: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11298
- UniProt Q9H3Y6: https://www.uniprot.org/uniprotkb/Q9H3Y6/entry
- NCBI Gene 6725: https://www.ncbi.nlm.nih.gov/gene/6725
- Ensembl ENSG00000125508: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125508

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Chronic myeloid leukaemia (CML)](https://onco.cc/cancers/cml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/srms.json