# SS18

Source: https://onco.cc/targets/ss18/  
OnCo record `ss18` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.

## Summary

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.21, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SS18 subunit of BAF chromatin remodeling complex; SMARCL1
- Tags: cancer-genes-wave
- Symbol: SS18
- Class: transcription
- Biology: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Location: Nucleus (UniProt). Locus 18q11.2 (HGNC).
- Where found: Sarcomas: Open Targets association 0.61 with sarcoma (MONDO_0005089); Synovial sarcoma: Open Targets association 0.53 with synovial sarcoma (MONDO_0010434)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11340: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11340
- UniProt Q15532: https://www.uniprot.org/uniprotkb/Q15532/entry
- NCBI Gene 6760: https://www.ncbi.nlm.nih.gov/gene/6760
- Ensembl ENSG00000141380: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141380

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Synovial sarcoma](https://onco.cc/cancers/synovial-sarcoma/)

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JSON: https://onco.cc/api/v1/entities/ss18.json