# SSTR4

Source: https://onco.cc/targets/sstr4/  
OnCo record `sstr4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SSTR4 (Somatostatin receptor type 4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.

## Summary

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.59, clinical 0.90).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: somatostatin receptor 4; Somatostatin receptor type 4
- Tags: cancer-genes-wave
- Symbol: SSTR4
- Class: other
- Biology: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumour cells. Location: Cell membrane (UniProt). Locus 20p11.21 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.59 with neuroendocrine neoplasm (MONDO_0019496)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11333: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11333
- UniProt P31391: https://www.uniprot.org/uniprotkb/P31391/entry
- NCBI Gene 6754: https://www.ncbi.nlm.nih.gov/gene/6754
- Ensembl ENSG00000132671: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132671

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)

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JSON: https://onco.cc/api/v1/entities/sstr4.json