# SSTR5

Source: https://onco.cc/targets/sstr5/  
OnCo record `sstr5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SSTR5 (Somatostatin receptor type 5) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.

## Summary

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerisation.

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Pasireotide. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.00, clinical 0.91). In OnCo, 1 product record names it (Pasireotide).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: somatostatin receptor 5; Somatostatin receptor type 5
- Tags: cancer-genes-wave
- Symbol: SSTR5
- Class: other
- Biology: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerisation. Location: Cell membrane (UniProt). Locus 16p13.3 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.60 with neuroendocrine neoplasm (MONDO_0019496); CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.97; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11334: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11334
- UniProt P35346: https://www.uniprot.org/uniprotkb/P35346/entry
- NCBI Gene 6755: https://www.ncbi.nlm.nih.gov/gene/6755
- Ensembl ENSG00000162009: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162009

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)
- drugs: [Pasireotide](https://onco.cc/drugs/pasireotide/)

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JSON: https://onco.cc/api/v1/entities/sstr5.json