# SSX2

Source: https://onco.cc/targets/ssx2/  
OnCo record `ssx2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.

## Summary

Could act as a modulator of transcription.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SSX family member 2; HOM-MEL-40; HD21; MGC3884; MGC15364; MGC119055; CT5.2a
- Tags: cancer-genes-wave
- Symbol: SSX2
- Class: transcription
- Biology: Could act as a modulator of transcription. Location: Nucleus (UniProt). Locus Xp11.22 (HGNC).
- Where found: Sarcomas: Open Targets association 0.61 with sarcoma (MONDO_0005089); Synovial sarcoma: Open Targets association 0.53 with synovial sarcoma (MONDO_0010434)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11336: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11336
- UniProt Q16385: https://www.uniprot.org/uniprotkb/Q16385/entry
- NCBI Gene 6757: https://www.ncbi.nlm.nih.gov/gene/6757
- Ensembl ENSG00000241476: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000241476

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Synovial sarcoma](https://onco.cc/cancers/synovial-sarcoma/)
- trials: [GHSG HD21](https://onco.cc/trials/hd21/)

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JSON: https://onco.cc/api/v1/entities/ssx2.json