# STIL

Source: https://onco.cc/targets/stil/  
OnCo record `stil` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.

## Summary

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.90).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: STIL centriolar assembly protein; SCL-interrupting locus protein; MCPH7
- Tags: cancer-genes-wave
- Symbol: STIL
- Class: other
- Biology: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cell cortex (UniProt). Locus 1p33 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908); Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10879: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10879
- UniProt Q15468: https://www.uniprot.org/uniprotkb/Q15468/entry
- NCBI Gene 6491: https://www.ncbi.nlm.nih.gov/gene/6491
- Ensembl ENSG00000123473: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123473

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/stil.json