# STMN1

Source: https://onco.cc/targets/stmn1/  
OnCo record `stmn1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

STMN1 (Stathmin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer.

## Summary

Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: stathmin 1; Stathmin; OP18; PR22; PP19; PP17; Lag; FLJ32206; LAP18; C1orf215
- Tags: cancer-genes-wave
- Symbol: STMN1
- Class: other
- Biology: Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1p36.11 (HGNC).
- Where found: Endometrial cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6510: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6510
- UniProt P16949: https://www.uniprot.org/uniprotkb/P16949/entry
- NCBI Gene 3925: https://www.ncbi.nlm.nih.gov/gene/3925
- Ensembl ENSG00000117632: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117632

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/)

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JSON: https://onco.cc/api/v1/entities/stmn1.json