# STRN

Source: https://onco.cc/targets/strn/  
OnCo record `strn` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.

## Summary

Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.

Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.91, genetic association 0.51, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: striatin; Striatin; PPP2R6A; STRN1
- Tags: cancer-genes-wave
- Symbol: STRN
- Class: other
- Biology: Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Membrane; Cell projection, dendritic spine (UniProt). Locus 2p22.2 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.54 with thyroid cancer (MONDO_0002108); Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11424: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11424
- UniProt O43815: https://www.uniprot.org/uniprotkb/O43815/entry
- NCBI Gene 6801: https://www.ncbi.nlm.nih.gov/gene/6801
- Ensembl ENSG00000115808: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115808

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Thyroid cancer](https://onco.cc/cancers/thyroid/)

---
JSON: https://onco.cc/api/v1/entities/strn.json