# STX-005

Source: https://onco.cc/drugs/stx-005/  
OnCo record `stx-005` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

STX-005 is an experimental circular mRNA circuit for in vivo CAR-T from Strand Therapeutics, in preclinical development for haematological malignancies.

## Summary

STX-005 is a circular mRNA circuit for in vivo CAR-T (systemic) from Strand Therapeutics. A systemically delivered circular mRNA circuit designed to generate CAR-T cells inside the body. Its furthest stage is preclinical development, for haematological malignancies. No clinical trial naming it is registered on ClinicalTrials.gov. No registry entry; the company's site links an April 2026 press release on preclinical in vivo CAR-T data at ASGCT 2026 (BusinessWire blocked the fetch, so only the headline/URL was seen). It has not been shown to work in people.

## Fields

- Kind: Treatment
- Status: preclinical
- Last checked: 2026-11-03
- Tags: pipeline
- Code: STX-005
- Modality: Circular mRNA circuit for in vivo CAR-T (systemic)
- Mechanism: A systemically delivered circular mRNA circuit designed to generate CAR-T cells inside the body.

## Sources

- Strand Therapeutics: strandtx.com: https://www.strandtx.com/pipeline
- Strand Therapeutics: strandtx.com: https://www.strandtx.com/pipeline

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- companies: [Strand Therapeutics](https://onco.cc/companies/strand-therapeutics/)

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